APACs – advantages for management of blood clots or thrombus related to vascular interventions
Normally blood flows smoothly through blood vessels. However, thrombosis, which is the formation of a blood clot inside a blood vessel, obstructs the efficient flow of blood. This can have serious health consequences and even cause death.
Current antithrombotic therapies can be grouped into one of two classes: 1) Antiplatelet drugs to prevent blood clots developing in arteries; and 2) Anticoagulant drugs to prevent blood clots developing in veins or those caused by heart arrhythmia, such as atrial fibrillation.
Under normal conditions, specific activation, adhesion and aggregation of platelets and subsequent coagulation activity ensue to heal a vascular injury by creating a seal. When a clot or thrombus forms during vascular intervention related injury, the above mechanisms are exaggerated.
Subsequently, the activation of both platelets and coagulation cascade leads to the deposition and maturation of fibrin to stabilize the clot. As thrombus consists of platelets and fibrin, the optimum antithrombotic therapy should be directed towards both.