Publications

Chen J, Verni CC, Jouppila A, Lassila R, Diamond SL. Dual antiplatelet and anticoagulant (APAC) heparin proteoglycan mimetic with shear-dependent effects on platelet-collagen binding and thrombin generation. Thromb Res. 2018 Jul 25; 169:143-151. read more

Tuuminen R, Jouppila A, Salvail D, Laurent C E, Benoit M C, Syrjälä S, Helin H, Lemström K, Lassila R. Dual antiplatelet and anticoagulant APAC prevents experimental ischemia-reperfusion-induced acute kidney injury. Clin Exp Nephrol. 2017 Jun;21(3):436-445. read more

Lassila R, Jouppila A. Mast cell-derived heparin proteoglycans as a model for a local antithrombotic. Semin Thromb Hemost. 2014 Nov;40(8):837-44.

Olsson E, Asko-Seljavaara S, Lassila R. Topically administered macromolecular heparin proteoglycans effectively inhibit thrombus growth in microvascular anastomoses. Thromb Haemost, 2002, 87;245-51.

Kauhanen P, Kovanen PT, Lassila R. Coimmobilized native macromolecular heparin proteoglycans strongly inhibit platelet interactions under flowing blood. Arterioscler Thromb Vasc Biol, 2000, 20:e113-e119.

Kauhanen P, Kovanen PT, Reunala T, Lassila R. Effects of cutaneous mast cells on bleeding time and coagulation activation at the site of platelet plug formation. Thromb Haemost, 1998, 79:843-7.

Lassila R, Lindstedt K, Kovanen PT. Native macromolecular heparin proteoglycans exocytosed from stimulated rat serosal mast cells strongly inhibit platelet-collagen interactions. Arterioscler Thromb Vasc Biol, 1997, 17:3578-87.

2017 International Society of Thrombosis and Hemostasis (ISTH) Congress

K.A. Barreiro, A. Jouppila, R. Tulamo, A. Albäck, R. Lassila APAC, a Dual Antiplatelet and Anticoagulant Heparin Proteoglycan Mimetic, Integrates with Extravascular Matrix during Vascular Injury. PB 1629. (2017) Abstracts. Res Pract Thromb Haemost, 1: 1405. doi:10.1002/rth2.12012 view poster

N.R. Bonetti, A. Jouppila, S. Gobbato, S. Stivala, G.G. Camici, R. Lassila and J.H. Beer. A Dual Antiplatelet (AP) and Anticoagulant (AC) Compound – APAC – Inhibits Collagen-induced Platelet Aggregation in Mice and Protects against Arterial Thrombosis. PB 082. (2017) Abstracts. Res Pract Thromb Haemost, 1: 349 – 350. doi:10.1002/rth2.12012 view poster

A. Jouppila, M. Lemponen, K. Barreiro, R. Lassila APAC, a Dual Antiplatelet and Anticoagulant Attenuates Collagen-induced Platelet Aggregation and Fibrin Elasticity in Blood. PB 2204. (2017) Abstracts. Res Pract Thromb Haemost, 1: 1275. doi:10.1002/rth2.12012 view poster

Platelets 2016 9th International Symposium

A. Jouppila, K. Barreiro, R. Tulamo, A. Albäck, and R. Lassila. APAC, a Dual Antiplatelet and Anticoagulant Heparin Proteoglycan Mimetic Targets Von Willebrand Factor in Injured Vessel Wall view poster

2015 International Society of Thrombosis and Hemostasis (ISTH) Congress

Jouppila A, Benoit M-C, Laurent CE, Salvail D and Lassila R. Pharmacokinetics and pharmacodynamics of APAC, a dual novel anticoagulant and antiplatelet heparin complex. PO081-WED. (2015) J Thromb and Haemost, 13 (Suppl. 2): 783 view poster